What happens if the vaccine is given before or after the patient arrives at their destination? Hospitalcan protect them from Deadly ‘superbugs’ What’s lurking in the healthcare environment?
This is the premise behind experimental vaccine Invented by a team led by the University of Southern California. Researchers designed the formula to prevent serious infections caused by drug-resistant pathogens.A new study published in Science Translational Medicineshowing that a single dose administered in a mouse model can place immune cells into ‘The Incredible Hulk’, Provides fast protection against eight different bacteria and fungi.
«This is an early warning system. It’s like the Department of Homeland Security issued a terrorist alert. ‘Everyone must keep their eyes open.Keep an eye out for suspicious packages,” said the lead author Brad Sperberg, Medical Director of the University of Southern California Los Angeles General Medical Center (formerly LAC+USC). “You’re alerting soldiers and tanks to your immune system. The vaccine activates them. “I mean, when you have bad ‘superbugs’ lurking, that’s when you want the ‘Hulk’ waiting to attack. “
In many cases, the infection is caused by so-called “superbugs” such as MRSA (short for methicillin-resistant Staphylococcus aureus) or Acinetobacter baumannii, and the infection spreads through contaminated surfaces or equipment, such as catheters or ventilator) or spread from person to person. to person. ICU patients are at the highest risk and may suffer from operating room infections, bloodstream infections, urinary tract infections, and ventilator-associated pneumonia.
Use the immune system
The experimental vaccine takes a completely different approach: It taps into the body’s pre-existing immune cells that engulf pathogens, called MacrophagesIt engulfs and digests bacteria, fungi and other harmful substances, the scientists explained in a statement. These activated fighters are found in all tissues and are able to quickly eliminate invaders that might otherwise multiply rapidly and overwhelm the body’s defenses.
“This is very different from the development of new antibiotics,” said Jun Yan, a doctoral student at the Keck School of Medicine of USC and first author of the study. “This is using our own immune systems to fight different ‘superbugs’ in a way that’s different from others.”
This is the vaccine
The vaccine consists of only three ingredients, two of which are already used in FDA-approved vaccines. The third ingredient is a small surface patch of fungus commonly found on human skin.
The vaccine takes effect within 24 hours and is effective for up to 28 days
The vaccine was tested in two independent laboratories and is suitable for 24 hours, lasts up to 28 days. In laboratory models, immune cells that feed on pathogens in the blood dramatically increase in number and improve survival of invasive infections in the blood and lungs. Early data suggests the second dose of the vaccine can extend the window of protection against infection.