Categories: HEALTH

Immune Globulin – How and When to Give After Hours

Post-exposure prophylaxis after working hours

Rabies and immunoglobulin services (outsideImmunoglobulin S) during working hours, clinical advice is available on the website and through the Colindale On-call Doctor Service on evenings, weekends and public holidays.All vaccine and immune globulin questions, except antitoxins (botulinum or diphtheria), can wait until the next day, so advice after 5.30pm callers should wait and call us the next morning Immunoglobulin S or Colindale on-call doctor service.

No need to call Immunoglobulin S If notified before the next working day of rabies vaccination, and any vaccine administered in good faith as part of post-exposure treatment for rabies, the team will replace the vaccine. If vaccines and/or immunoglobulins are required outside of working hours and cannot wait until the next working day, the products can be collected from local stockists or delivered the next day via Movianto.

UK Health and Safety Executive (british health and safety agency) cannot issue products to hospitals or GP surgeries outside England.

Hepatitis A

Hepatitis A vaccination can prevent hepatitis A infection in close contacts and household contacts if given within 14 days of exposure. Human normal immunoglobulin (High voltage NIG) is used to further attenuate infection in people who are at higher risk for severe hepatitis A (people with underlying liver disease) and in people who are slower to respond to the vaccine (people 60 years and older or people with liver disease or immunosuppression).

High voltage NIG Hepatitis A problem

Contacts 60 years and older

Exposed persons should receive the first dose of vaccine (locally procured) within 14 days of exposure.

High voltage NIG Calls received after the required cut-off time of 14 days from the date of onset of jaundice will not be issued at all.

Exposure to underlying liver disease and immunosuppression

Exposed persons should receive the first dose of vaccine (locally procured) within 28 days of exposure.

High voltage NIG Calls received after the required cut-off time of 28 days from the date of onset of jaundice will not be issued at all.

For more details please visit:

Public health control and management of hepatitis A.

Hepatitis A: Green Paper, Chapter 17.

measles

historical evidence shows High voltage NIG

If given within 4 to 5 days of exposure in the home environment, it may prevent or reduce meal intake. High voltage NIG Therefore, it is being offered to individuals who are at increased risk of severe dietary risk following contact with a case.However, due to variations in the donor population, the tolerated dose of intramuscular current High voltage NIG The level of measles antibodies in the preparation is insufficient to provide protection against infection.

immunosuppressed individuals

Immunosuppressed individuals should receive locally sourced intravenous immunoglobulinpreferably within 3 days of exposure

pregnant woman or baby

High voltage NIG Products are available on the NHS and should be available locally. A small amount of Subgam (High voltage NIG) can be issued through Movianto, but calls received after the cut-off time of the fifth day from the date of exposure will not be issued at all.

For more details please visit:

Postexposure Dietary Prevention Guidelines.

National Dietary Guidelines.

Hepatitis B

Infants are at high risk for hepatitis B infection

Neonatal hepatitis B vaccination is highly effective (greater than 90%) in preventing infection in infants born to infected mothers. In infants born to women with highly infectious markers, hepatitis B immune globulin (hepatitis B immune globulinVaccinations are also given in addition to vaccines to further reduce the risk of transmission.

The added benefit is hepatitis B immune globulin Hepatitis B vaccine has a minimal role in preventing perinatal hepatitis B transmission, so the first priority for these infants is timely vaccination with a birth dose of hepatitis B vaccine, which should be purchased locally.

hepatitis B immune globulin should be ordered via british health and safety agency In the antepartum period, when a pregnant woman is identified as having hepatitis B with evidence of high contagiousness (see Green Paper), the product is usually mailed to the requesting maternity unit approximately 8 weeks before the expected date of delivery (EDD).

hepatitis B vaccine, and hepatitis B immune globulin If needed, it is best given within 24 hours of birth, but it can be given later, although there is no evidence that the vaccine hepatitis B immune globulin Take it more than 7 days after birth to prevent infection. Consider delaying vaccination to prevent future exposure.

Other exposure groups

hepatitis B immune globulin In addition to the vaccine, it is also recommended for individuals who have been exposed (such as needle stick injuries) from a known hepatitis B-positive source or from an unknown source known to be unresponsive to vaccination.

Infants born to hepatitis B-infected mothers and other exposed persons

hepatitis B immune globulin It is usually issued prenatally and mailed to the hospital before the baby is delivered.if hepatitis B immune globulin It has been noted but cannot be provided on site. Vaccination should be administered as soon as possible and the source arranged. hepatitis B immune globulin by calling Immunoglobulin S Contact the team or on-call doctor from 9:00pm to 5:30pm, 7 days a week.

Other exposure groups

Outside working hours, contacts should receive a first dose of vaccine (locally procured).If necessary, sources should be arranged hepatitis B immune globulin Best by calling Immunoglobulin S Contact the team or on-call doctor from 9:00pm to 5:30pm, 7 days a week. hepatitis B immune globulin

Vaccination should be given within 24 to 48 hours after vaccination.Non-responders who received their first dose of drug hepatitis B immune globulin If the source is confirmed positive and no response to the booster vaccine is documented, arrangements should be made to receive a second dose.

For more details please visit:

Hepatitis B immune globulin (hepatitis B immune globulin) for babies born to mothers infected with hepatitis B

Hepatitis B: guidance, data and analysis

Rabies

Rabies vaccine is a major component of rabies post-exposure treatment; additional benefits of human rabies immune globulin (HRIG) is to eliminate local viruses at the point of contact.

many Global Positioning System All hospital trusts should have local stocks of vaccine and these stocks should be used wherever possible.In this case, the government will require replacement of the rabies vaccine Immunoglobulin S team if contacted the next business day.

Ideally, treatment should be started within 24 hours of presentation, except for high-risk head and neck exposure, in which case treatment should be started as soon as possible.

For previously untreated patients

Check to see if the vaccine is available locally and use it if possible. Colindale will replace any vaccine used in good faith for post-exposure treatment.It is more important to start vaccination now than to try to procure the vaccine HRIG Can be ordered via Immunoglobulin S Team up the next day if necessary.No need to contact Immunoglobulin S Team before vaccination

For individuals who have received their first dose of post-exposure treatment

2nd dose of vaccine (and HRIG If needed) will usually be distributed via Movianto on the next working day, unless this means the vaccine may be delayed more than 48 hours from the expected date.In this case, vaccines (and HRIG If required) should be obtained as described above.

If instructed, HRIG This is only required within the first 7 days after the first dose of vaccine. For calls received after the day’s issue closes, HRIGIf necessary, it will be sent out for collection the next day. HRIG Calls received after the cut-off time of the sixth day from the date of first dose of vaccine will not be received.

The 3rd, 4th or 5th dose of vaccine will always be distributed on the next business day.

For patients who have received pre-exposure vaccination

The first dose of post-exposure vaccination is generally available by the next business day Immunoglobulin S team, unless this would result in a delivery delay of more than 48 hours (e.g. during a bank holiday weekend), in which case the product may be collected from the local shareholder or dispatched outside Movianto working hours for next day delivery.

The 2nd dose is always given out on the next business day.

For more details please visit:

Guidelines for the management of rabies post-exposure treatment.

Varicella Zoster

Immunosuppression and pregnant contacts

Oral acyclovir or valacyclovir is now recommended for susceptible immunosuppressed individuals and all pregnant women unless there is serious concern for nephrotoxicity or malabsorption.

For those identified as susceptible and those who would otherwise be offered varicella zoster immune globulin (VZIG), antiviral drugs (oral acyclovir or valacyclovir) should be given on days 7 to 14 after exposure. If the patient is seen on the 7th day after exposure, a 7-day course of antiviral medication can be started on the 14th day after exposure, if necessary.

Infant and neonatal contacts

post-exposure prophylaxis VZIG Testing is generally not needed for newborns born more than 7 days after the mother developed chickenpox, or for newborns whose mothers developed shingles around the time of delivery, because these newborns will produce maternal antibodies. VZIG Applicable only if the newborn is directly exposed during the first week of life.

post-exposure prophylaxis VZIG Not suitable for use in newborns (less than 7 days old) whose mothers were exposed to varicella-zoster virus antibodies during pregnancy (Varicella zoster virus IgG) negative unless the mother has chickenpox.

If the mother develops chickenpox between 4 days before and 2 days after delivery, prophylactic acyclovir (10 mg/kg 8 times hourly for 10 days) should be considered. Additionally, acyclovir should be considered for use in mothers (see Pregnancy section).

For more details please visit:

Post-exposure prophylaxis guidelines (PEP) for chickenpox and shingles.

other products

diphtheria

Diphtheria antitoxin is available for emergency distribution on weekends and non-working hours.If there is no local shareholder, 5-hour delivery can be arranged on weekends and bank holidays battery management system Arrive at any time.

For more details please visit:

Diphtheria antitoxin (data transmission technology): Information for healthcare professionals

Guidelines for public health control and management of diphtheria

Botulism

If required, botulinum antitoxin should be issued on an emergency basis by one of the local shareholders on weekends and out of hours – a list of these is available on the intranet.In case there are no local shareholders, 5-hour delivery can be arranged on weekends and bank holidays battery management system Arrive at any time.

For more details please visit:

Botulism: clinical and public health management