Navarra can eliminate hepatitis C infection

HCV infection could be eliminated by 2030 navarre.This concludes the doctoral dissertation “Evaluation of the hepatitis C virus elimination process in Navarre”defended by Public University of Navarra (UPNA) go through Christina Burj Alcaidegraduated from pharmacy and graduated from Human Nutrition and Diet.In this way, the work reflects that, due to the elimination of infection navarre By 2030, set goals World Health Organization (WHO).

As the authors of the paper explain, in order to achieve the above goals, it is necessary to overcome a series of obstacles, such as detecting undiagnosed infectioncapture lost-to-follow-up cases, initiate and adhere to treatment, and prevent new HCV infections (Hepatitis C virus).The ability to care for both navarre This can be achieved thanks to available drugs, but for this, “it is necessary to resume a more stringent rhythm of diagnosis and treatment of active infections”, he assures christina bourgeois.

According to preliminary epidemiological studies carried out in the paper, the number of people with a history of confirmed infection Hepatitis C virus exist navarre From 2,014 in 2015 to 2,321 in 2022, but the number of people with active infections has decreased by 84% over the same period. As the paper’s authors point out, this is due in large part to the commercialization of direct-acting antivirals that began in 2013, resulting in well-tolerated and high success rates of oral drug therapy.

Christina Burgi: “Need to resume a more intensive active infection diagnosis and treatment rhythm to achieve the goal”

In addition to this epidemiological study, the doctoral dissertation completed three observational analyzes of the population served Navarre Health Services, where an anonymous healthcare database is used. In the first analysis, diagnostic activity for active HCV infection was assessed on the basis of test results performed on patients with: primary health care and specialized The period 2017-2019 has varying degrees of suspicion, making it possible to assess the diagnosis rate and estimate the prevalence undiagnosed infection.

network of primary health care More than half of the new diagnoses were 1 active infection detected per 433 analyzed patients, compared with only 1 new active infection detected per 1,880 analyzed patients in preoperative testing.The results of these preoperative analyzes allowed us to estimate navarre Between 200 and 300 people, most of whom were born before 1980, had an undiagnosed active infection between 2017 and 2019.

The second method evaluates interventions proposed by the Ministry of Health healthyrecruiting patients with incomplete diagnoses Hepatitis C virus Complete a diagnosis and refer those diagnosed for medical treatment. A review of old laboratory results identified 281 patients with incompletely diagnosed HIV infection. Hepatitis C virus Sometimes there are no good treatment options.

As of the time of this assessment, 67% of them had been exposed, 28% had an active infection and were referred for treatment, 40% had a false positive, and 31% had recovered from the infection spontaneously. “This intervention is a very effective measure, both personally and professionally enriching, because it allows people who do not know they have the virus to be diagnosed with an active infection, preventing them from becoming infected over time. progression to severe stages such as cirrhosis and hepatocellular liver disease. Cancer,” Target christina bourgeois.

“Coordination and close cooperation between different health professions has made it possible to maintain good rates of diagnosis and treatment of infections caused by COVID-19. Hepatitis C viruspartly affected by the Covid-19 pandemic,” he concluded.

Elimination of HCV infection in well-organized healthcare settings is possible, and its achievement depends on the prioritization of this goal.

The third method assessed the effectiveness of the treatment antiviral drugs direct action initiated Navarra University Hospital Between 2015 and 2020 and follow up to 2021 to verify how many cases persistent viral response, referring to the cure of the infection. 1,366 patients started treatment, 19% of whom also had COVID-19 human immunodeficiency virus (HIV).

96.6% of patients who initiated treatment and 97.7% of patients who completed follow-up achieved this goal persistent viral response. After repeating the treatment for patients who failed the first time, the cure rate reached 100%. The drugs showed a good safety profile, as only three of the total number of patients treated had to change treatment due to adverse effects.

The paper concludes that current diagnostic and therapeutic tools make it possible to eliminate bacterial infections. Hepatitis C virus As noted, in well-organized health settings, “depending on whether they achieve this priority” christina bourgeois.

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