The scientists responsible for cloning Dolly the sheep was offered to the british Government its findings on a possible treatment for the Covid-19 using immune cells from healthy young volunteers.
The researchers of the private lab TC Biopharm, located near Glasgow, have already used the new therapy -which used transfusions of immune cells – to successfully treat the cancer. As reported by the Daily Telegraphthe experts now expect that it will also work against the coronavirus, and is in talks with the Government to test the therapy to that end.
The expert Brian Kelly, a medical advisor strategic of TC Biopharm, said that “one of the main challenges of the fight against viral infection is to develop something that attack the infected cells and not normal cells”.
“So the solution we came up with was to look at the body’s natural defenses to viral infection”, he explained and added that there is a very small subset of gamma delta T cells which are the first line of defense in viral infection. In patients that have fought with success against a viral infection, he explained, have expanded their own immune system and that persists after to avoid getting infected again.
The donor T cells differ from cells in normal immune, since they do not identify invaders in the body based on the bumps on the surface of the cells, but by detecting the metabolism of unusual viruses, explained the specialist. “When the donor’s cells detect a virus, they begin to destroy it while also pointing to the rest of the immune system as an intrusion of alien that needs to be eradicated”.
Kelly said that with this approach, even if the virus mutates and returns to the body, the transfusion may be repeated and would still function.
Doctors can infuse the cells of a patient in a single session of one hour duration, with TC Biopharm that already has a license to perform this type of treatment.
TC Biopharm was founded in Edinburgh in 1996 by Angela Scott, who was part of the team that cloned Dolly the Sheep. The same Dolly was suffering from a pulmonary disease induced by a virus.
Dolly has continued to inspire the scientific research for 20 years after it was revealed to the world in 1997, having been born in 1996. Its creation has been fundamental to the stem cell research and opened up possibilities previously unimaginable in biology and medicine.
Was named in honor of Dolly Parton, the curvaceous singer country north american, because the adult cell used was a mammary gland. His birth sparked a furious debate about the ethics of cloning, a dispute that deepened with the possibilities of human cloning.
Dolly was a kind of medical wonder, since that was the only lamb a survivor of 277 attempts to clone and was created from a cell taken from a sheep Finnish of six years. The pioneering technique which used the team of Roslin involved transfer of the nucleus of an adult cell to an egg not fertilized had removed the nucleus itself. An electric shock stimulated the hybrid cell to start dividing and to generate an embryo which is then implanted in the uterus of a mother surrogante.
Dolly suffered from arthritis and a lung disease induced by a virus and, finally, died 14 February 2003.
Fear in the United kingdom by the increase of dead by COVID-19
The United Kingdom registered for the first time this Saturday more than 700 sick of coronavirus dead in a day, putting in evidence the rapid increase of the mortality linked to the covid-19 in the country. A total of 708 people infected died in 24 hours, bringing the total balance in the country in 4.313 dead, announced the health authorities in britain.
Prime minister Boris Johnson, who is at his home recovering from the disease, asked the people to stay in their homes.
Meanwhile, the adviser to the british Government and professor of mathematical biology at Imperial College, Neil Ferguson, has estimated that the country will take between seven and 10 days to begin to flatten the curve of infections.
“We believe that this epidemic in the United Kingdom will stabilize in the next week to 10 days,” he explained in an interview to the BBC, although failing to be more accurate given the fluidity of the situation.
“It is not yet clear whether we will see a long peak and plain, or, as we hope, we will experience a decrease much faster,” he explained.