according to National Autonomous University of MexicoDiclofenac sodium is an anti-inflammatory drug with analgesic and antipyretic activity, suitable for oral and intramuscular injection. used to treat diseases Acute rheumatic disease, rheumatoid arthritis, ankylosing spondylitis, osteoarthritis, low back pain, gout in the acute phase, post-traumatic and post-operative inflammation, renal and biliary colic, acute migraine, and post-operative pain and dysmenorrhea prevention.
What are the contraindications of diclofenac sodium?
he Diclofenac Sodium Patients with gastric or intestinal ulcers, known hypersensitivity to active substances, pyrosulfites and other excipients are contraindicated.
return Contraindicated in patients with asthma, urticaria or acute rhinitis After taking acetylsalicylic acid or other drugs that inhibit prostaglandin synthase. Severe arterial hypertension, heart, kidney, and liver failure, cytopenias.
What are the general precautions for diclofenac sodium?
same National Autonomous University of Mexico Ensure that the gastrointestinal effects of diclofenac sodium are most common when taken orally. Bleeding, ulceration, or perforation of the bowel wall was observed.
you must be careful Patients with hepatic and renal insufficiency. After chronic ingestion for more than 8 weeks, the effect of transaminases should be assessed and the drug should be discontinued if transaminase levels are abnormal.
What are the side effects of diclofenac sodium?
- Gastrointestinal: Epigastric pain, other gastrointestinal disorders such as nausea, vomiting, diarrhea, abdominal cramping, dyspepsia, flatulence, and anorexia. Rarely: Gastrointestinal bleeding (hematemesis, melena, bloody diarrhea), stomach or intestinal ulcers, with or without bleeding or perforation. Individual cases: aphthous stomatitis, glossitis, esophageal lesions, intestinal strictures due to deformation of the “septum”, nonspecific hemorrhagic and ulcerative colitis or lower intestinal disorders such as exacerbation of Crohn’s disease, constipation and pancreatic inflammation.
- Central Nervous System: Occasionally: Headache, dizziness, or vertigo. Rarely: drowsiness. Individual cases: Sensitivity disorders, including paresthesias, memory disturbances, disorientation, insomnia, restlessness, seizures, depression, anxiety, nightmares, tremors, psychotic reactions, aseptic meningitis.
- Special senses: individual cases: visual impairment (blurred vision, diplopia), hearing loss, tinnitus, taste disturbance.
- Skin: Occasionally: Erythema or rash. Rare: urticaria. Individual cases: Bullous rash, eczema, erythema multiforme, Stevens-Johnson syndrome, Lyell syndrome (acute toxic epidermolysis), erythroderma (exfoliative dermatitis), alopecia, photosensitivity reactions ; Purpura, including allergic purpura.
- Hematology: individual cases: thrombocytopenia, leukopenia, anemia (hemolytic, aplastic), agranulocytosis.
- Kidney: Individual cases: acute renal failure, urinary disorders such as hematuria, proteinuria, interstitial nephritis, nephrotic syndrome, and papillary necrosis.
- Liver: Occasionally: Elevated serum transaminase values. Rare: hepatitis with or without jaundice. Individual cases: fulminant hepatitis.
- Hypersensitivity Reactions: Rare: Hypersensitivity reactions such as asthma, anaphylaxis/anaphylactoid reactions, including hypotension. Isolated cases: vasculitis, pneumonia.
- Cardiovascular system: isolated cases: palpitations, chest pain, hypertension and congestive heart failure.
- Other Organ Systems: Occasionally: Reactions at the intramuscular injection site such as local pain and stiffness. Individual cases: local abscess and necrosis at the site of intramuscular injection.