THURSDAY, Sept. 7, 2023 (HealthDay News) — The leading cause of hepatocellular carcinoma (HCC) in men remains hepatitis C virus (HCV), according to a study published online Sept. 7 Since 2015, the incidence of HCV-HCC has decreased. 5 inches Clinical Gastroenterology and Hepatology.
Paulo S. Pinheiro, MD, of the University of Miami School of Medicine, and colleagues examined the leading causes of each of the 14,420 HCC cases diagnosed in the Florida Cancer Registry from 2010 to 2018. Detailed ethnicity was assessed using age-adjusted incidence rates (AAIR). Examination of time trends for specific causes according to year of diagnosis.
Researchers found that the leading cause of HCC in men is still HCV, but since 2017, the leading cause of HCC in women is non-alcoholic fatty liver disease (NAFLD). HCV-HCC AAIRs are particularly high among U.S.-born minority men, including Puerto Ricans, African Americans, and U.S.-born Mexican Americans (10.9, 8.0, and 7.6 per 100,000). NAFLD is more common among all Hispanics and Filipinos, while hepatitis B virus (HBV)-HCC is more common among Asian and black Haitian men. In Asian women, HCV-HCC exceeds HBV-HCC. Since 2015, the population-based incidence of HCV-HCC has declined rapidly (-9.6% per year), while the incidence of alcohol-related liver disease-HCC and NAFLD-HCC has increased (+6.0% and 4.3%, respectively).
“Cancer control efforts should begin by expanding screening programs to the most vulnerable groups identified in the study,” co-author Patricia D. Jones, MD, of the University of Miami School of Medicine, said in a statement.
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